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Updated: May 15, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

反応性を犠牲にすることなくストレスを緩和する:ステレオ電子制御された移行状態の安定化経由で,迅速かつ調節可能な非触媒アルキネ-アジドサイクル添加物の設計

Brian Gold1, Gregory B Dudley, Igor V Alabugin

  • 1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.

Journal of the American Chemical Society
|January 1, 2013
PubMed
まとめ

研究者は,超結合とH結合を用いた移行状態 (TS) の安定化により,触媒なしのクリック反応を強化した. このモジュール式アプローチにより,調節反応性が可能になり,pHによって引き起こされる加速が観察されます.

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