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Updated: May 15, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Cas9によるRNA誘導ヒトゲノム工学

Prashant Mali1, Luhan Yang, Kevin M Esvelt

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|January 5, 2013
PubMed
まとめ

科学者たちは,ヒトゲノム編集のために,定期的に間隔の短いパリンドロームの繰り返し (CRISPR) システムを設計した. この新しいRNA誘導ツールは,ヒト細胞の精密で複数の遺伝子編集を可能にします.

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Genome Editing in Mammalian Cell Lines using CRISPR-Cas07:56

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

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Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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