アスピリンの長期使用と年齢関連の黄斑変性
Barbara E K Klein1, Kerri P Howard, Ronald E Gangnon
1Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726-2336, USA. kleinb@epi.ophth.wisc.edu
JAMA
|January 5, 2013
まとめ
10年以上にわたるアスピリンの定期的な使用は,遅年性黄斑変性 (AMD) リスクのわずかな増加と関連していました. しかし,5年以内にアスピリンの使用は,早期または遅いAMD発生率と関連性がないことが示されました.
科学分野:
- オフタルモロジック (眼科)
- エピデミオロジー エピデミオロジー
- 心血管の健康について
背景:
- アスピリンは通常,痛みを和らげ,心臓を保護するために使用されます.
- 眼科医は,眼科手術の前にアスピリンの使用,および年齢関連の黄斑変性 (AMD) 患者について懸念を表明しています.
研究 の 目的:
- 定期的なアスピリン使用と,年齢関連の黄斑変性 (AMD) の発生率との関連を調査する.
主な方法:
- ビーバー・ダム・アイ・スタディは,人口を対象とした20年間の長期研究で,43歳から86歳までの4926人の参加者を追跡した.
- 参加者はアスピリンの定期的な使用 (≥2回/週3ヶ月以上) を報告しました.
- 新血管性AMDおよび純粋な地理的縮を含む早期および遅期のAMDの発生率は,網膜写真を通じて評価されました.
主要な成果:
- 検査前の10年間,アスピリンの定期的な使用は,晚期AMD (HR, 1.63) と特に新血管AMD (HR, 2.20) のリスクの増加と関連していました.
- アスピリンの使用 (5年または10年前) と早期AMDの発生率との間に有意な関連性は見つかりませんでした.
- 10年前にアスピリンを使用した場合,使用者のAMDの発生率は1.76%と,使用しない人の1.03%と推定されています.
結論:
- 観察前の10年間,アスピリンの定期的な使用は,インシデント遅いおよび新血管性AMDのリスクの統計的に有意な,しかし小さな増加と関連しています.
- 観察された発生前の5年以内にアスピリンの使用は,早期または遅いAMDの発生と関連しませんでした.
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