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ビグアニドは,循環型AMPの産生を減少させることで,肝臓のグルカゴン信号伝達を抑制する

Russell A Miller1, Qingwei Chu, Jianxin Xie

  • 1Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Nature
|January 8, 2013
PubMed
まとめ

2型糖尿病の重要な薬であるメトホルミンは,グルカゴンの作用を阻害することによって,肝臓のグルコース産生を減少させます. これはAMPの蓄積によって発生し,周期的なAMPとタンパク質キナーゼAを阻害し,最終的に血糖を低下させます.

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