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Updated: May 4, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

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ルーベッラウイルスタンパク質E1の結晶構造からの機能的および進化的洞察

Rebecca M DuBois1, Marie-Christine Vaney, M Alejandra Tortorici

  • 1Institut Pasteur, Département de Virologie, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France.

Nature
|January 8, 2013
PubMed
まとめ

ルーベッラウイルスE1のグリコタンパク質構造は,そのユニークなクラスII融合タンパク質機構を明らかにします. この発見は,風疹ウイルスの侵入を理解し,先天性風疹症候群に対する新しい戦略を開発するために不可欠です.

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Viral Structure00:56

Viral Structure

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
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