高活性ルテニウムメタテシス触媒は,前例のない活性とZ選択性を示しています
Lauren E Rosebrugh1, Myles B Herbert, Vanessa M Marx
1Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Journal of the American Chemical Society
|January 16, 2013
まとめ
新しいルテニウム触媒は,メタテシス反応において高いZ-オレフィン選択性 (>95%) と例外的な活性 (7400トンまで) を提供します. 改良された合成方法により,オレフィンホモディメリゼーションの高度なZ選択的触媒が得られる.
科学分野:
- 有機金属化学 有機金属化学
- カタリシス科学 カタリシス科学
背景:
- ルテニウムベースの触媒は,オレフィン転化反応に不可欠です.
- 高度に選択的で活性な触媒の開発は,合成化学の主要な課題です.
研究 の 目的:
- 新しいN-2,6-ジソプロピルフェニル置換ケラートルテニウム触媒を報告する.
- ホモディメリゼーションおよび工業的に重要なメタテシス反応における性能を評価する.
- これらのルテニウム複合体の改良された合成方法を導入する.
主な方法:
- 新しいケラートルテニウム触媒の合成.
- 塩のメタテシスとC-H活性化のためにナトリウムカルボキシラートを利用する.
- 様々なメタテシス反応における触媒の選択性とターンオーバー数 (TONs) をテストする.
主要な成果:
- 新しい触媒は,ほぼ完璧なZ-オレフィン選択性 (>95%) を表しています.
- 計7400トンまでの比類のない売上高を達成しました.
- 末端オレフィンのホモディメリゼーションにおいて高いZ選択性を示した.
結論:
- 報告されたルテニウム触媒は,Z選択的転移に対して非常に有効である.
- 改良された合成法により,新しい触媒的に活性な種へのアクセスが容易になりました.
- この研究は,効率的で選択的なオレフィンメタテシス触媒の開発を進めています.
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