関連する実験動画

Updated: May 15, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

β-アレスティン-2の徴募またはフォスフォリパゼ-Cの活性化に関連した明確なCCK-2受容体構成は,バイアスしたアンタゴニストによって明らかになりました

Rémi Magnan1, Chantal Escrieut, Véronique Gigoux

  • 1EA 4552, Université de Toulouse 3, 31432 Toulouse, France.

Journal of the American Chemical Society
|January 18, 2013
PubMed
まとめ

7つのトランスメブラン受容体 (7TMRs) は結合時に異なる構造を採用し,偏った薬剤設計を可能にします. この研究は,標的型Gタンパク質またはβ-アレスティンシグナル伝達に不可欠なCCK2R構成の構造的な違いを明らかにしています.

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