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関連する概念動画

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

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関連する実験動画

Updated: May 15, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

腫瘍を促進する慢性炎症を中和する:魔法の弾丸?

Lisa M Coussens1, Laurence Zitvogel, A Karolina Palucka

  • 1Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA. coussenl@ohsu.edu

Science (New York, N.Y.)
|January 19, 2013
PubMed
まとめ

最近のがん治療法では,遺伝的逸脱や腫瘍の血管化を標的としています. 新しい免疫療法薬は,特定の免疫細胞が腫瘍の成長を促すという理解を活用し,がんに関連した炎症と闘うための新しい戦略を提供します.

科学分野:

  • 腫瘍学 腫瘍学
  • 免疫学 免疫学とは
  • がん研究 がん研究

背景:

  • 癌の診断と治療は,過去10年間で著しく進歩しました.
  • 現在の治療法は,化学療法,放射線,がん細胞内在の媒介者を標的とし,がん細胞外在の経路を調節する.
  • 慢性的に活性化された免疫細胞が腫瘍の発達を促進する役割を認識した免疫療法薬が登場しました.

研究 の 目的:

  • 癌に関連した炎症における免疫細胞の原始的役割に関する臨床的および実験的研究をレビューする.
  • これらの免疫細胞を標的とし,その機能を再プログラムする可能性を議論する.
  • 免疫細胞を再プログラムすることで,慢性炎症を中和し,癌の拒絶を促進する方法を探る.

主な方法:

  • 臨床試験のレビュー.
  • 実験研究の分析.実験研究の分析.
  • 免疫細胞のサブセットの原始的な役割の定義.
  • 免疫細胞の再プログラムのためのターゲティング戦略の議論.

主要な成果:

  • がんに関連した炎症における原始的な役割を果たす特定の免疫細胞のサブセットを特定しました.
  • これらの免疫細胞は,その機能を変更するために標的とされることが強調されました.

さらに関連する動画

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

関連する実験動画

Last Updated: May 15, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

  • これらの細胞を再プログラムすることで,がんを誘発する炎症を解消または中和することが示されました.

    • 結論:

    • 慢性炎症に関与する免疫細胞のサブセットを標的にすることは,有望な治療戦略を提供します.
    • これらの細胞を再プログラムすることで,がんを誘発する炎症の解消につながる可能性があります.
    • このアプローチは,がんの拒絶を促進し,治療結果を改善します.