運動トレーニングと抗高血圧薬療法の組み合わせ. 脂質,血圧,左心室質量への影響
M H Kelemen1, M B Effron, S A Valenti
1Department of Medicine, Columbia Medical Plan, Md 21045.
JAMA
|May 23, 1990
まとめ
運動と抗高血圧薬は,血圧に対する組み合わせた利点を提供しますが,プロプロノロールは,運動によるコレステロールの改善を阻害します. 運動訓練は高血圧の男性における左心房に悪影響を及ぼさなかった.
科学分野:
- 心臓病学 心臓病学
- 運動生理学 運動生理学
- 薬理学 薬理学とは
背景:
- 高血圧の管理には,しばしば薬剤療法とライフスタイルの変更が含まれます.
- 心血管の健康マーカーに対する運動と抗高血圧薬の組み合わせによる影響については,さらなる調査が必要である.
研究 の 目的:
- 運動と抗高血圧薬の併用が,血圧の追加的な利点をもたらすかどうかを判断する.
- 薬物療法が運動による脂質プロファイルの改善に影響するかどうかを評価する.
- 高血圧の男性における左心室の構造と機能に対する運動トレーニングの効果を評価する.
主な方法:
- 52人の高血圧患者はランダムにディルチアゼム,プロプラノロール,またはプラセボを投与されました.
- 参加者は,ウェイトトレーニングとウォーキング/ジョギングを含む10週間の運動プログラムに従事した.
- 血圧,脂質プロファイル,左心室質量/透析機能が評価されました.
主要な成果:
- 運動訓練はすべてのグループで血圧を低下させた.
- 全体とLDLコレステロールは,すべてのグループで運動によって減少した.
- HDLコレステロールはプラセボとディルチアゼムで改善したが,プロプラノロールでは改善されなかった.
- 左心室の質量は増加し,腹動脈機能は運動で変わらない.
結論:
- 抗高血圧薬療法は,運動以外の追加の血圧低下をもたらさなかった.
- プロプラノロールは,HDLコレステロールにおける運動による有益な変化を制限しました.
- 運動トレーニングは,このコホートにおける左心房構造や腹動機能に悪影響を及ぼさなかった.
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