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Updated: May 14, 2026

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

非対称なリガンド結合は,ペンタメリカのリガンドゲートイオンチャネルにおける構成的移行を容易にする

David Mowrey1, Mary Hongying Cheng, Lu Tian Liu

  • 1Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Journal of the American Chemical Society
|January 24, 2013
PubMed
まとめ

プロポホルがGLICチャネルに非対称的に結合し,対称的結合ではなく,チャネル閉塞を引き起こします. 結合部位におけるこの対称性の破裂は,チャネルの適合性を変化させることで,機能的阻害を引き起こします.

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Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
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Cooperative Allosteric Transitions01:58

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Cooperative Allosteric Transitions01:58

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