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Updated: May 14, 2026

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

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G-overhangアーキテクチャに対する高解像度の洞察力

Robert Hänsel1, Frank Löhr, Lukáš Trantirek

  • 1Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt/Main, Germany. rhaensel.bpc@gmail.com

Journal of the American Chemical Society
|January 24, 2013
PubMed
まとめ

細胞内分子混雑は,テロメアG四重複 (G4) DNAの折りたたみに影響する. 希釈溶液は生理学的条件を模倣し,G4DNAがハイブリッド-1および並列プロペラ構造を採用していることを明らかにします.

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Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Disassembly of Intermediate Filaments

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Chromatin Structure and RNA Splicing

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Gene Duplication and Divergence

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The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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