トンネブルな信号処理は,転写因子転位のモジュール制御を介して行われます
Nan Hao1, Bogdan A Budnik, Jeremy Gunawardena
1Harvard University Faculty of Arts and Sciences Center for Systems Biology, Cambridge, MA 02138, USA.
Science (New York, N.Y.)
|January 26, 2013
まとめ
イーストの転写因子Msn2は,調節可能な信号プロセッサとして機能し,核輸送の二重調節を通じて,異なるストレス信号に機能を適応させます. これにより,環境変化に対する多面的な対応が可能になります.
科学分野:
- 分子生物学は分子生物学である.
- セルラー・シグナリング
- システム生物学 システム生物学
背景:
- 信号伝達経路は,多種多様な転写因子 (TF) アクティベーションダイナミクスを生成します.
- TFが信号を処理してさまざまな反応を生成する方法を理解することは極めて重要です.
研究 の 目的:
- 転写因子が信号入力を処理し,多様なダイナミックな応答を生成する方法を調査する.
- イーストTF Msn2.2における調節可能な信号処理のメカニズムを解明する.
主な方法:
- 発芽酵母における一般的ストレス反応性TF Msn2を研究した.
- 信号入力に対する応答として,TFアクティベーションのダイナミクスを分析した.
- リン酸化による二重規制 (核の輸入/輸出) の役割を調査した.
主要な成果:
- Msn2は,調節可能な信号プロセッサとして機能し,入力タイプに基づいて信号を追跡,フィルタリング,または統合することができます.
- ミュータント分析は,核の輸入または輸出の規制だけでは,Msn2を単一の信号処理機能に制限することを明らかにしました.
- リン酸化による二重調節により,Msn2の多用途な信号処理が可能になる.
結論:
- Msn2の調節可能な信号処理は,様々な自然のストレスに対する明確なダイナミックな反応を生成するために不可欠です.
- 複雑な信号処理機能は,単一の分子に統合することができます.
- 発見は",プログラム可能な"信号処理能力を持つTFの設計を導く.
関連する概念動画
02:33Combinatorial Gene Control
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
01:30General Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:16Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
02:16Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...