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Updated: May 14, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
10:04

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

アロマティック・スルフォニル・フッ化物は,トランスチレチンを共振的に運動的に安定させ,アミロイドゲネシスを防止し,同時に光結合体を供給する

Neil P Grimster1, Stephen Connelly, Aleksandra Baranczak

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 29, 2013
PubMed
まとめ

研究者らは,トランスチレチン (TTR) を選択的に結合し,共性結合体を形成する新しい1,3,4-オキシジアゾールを開発した. これらの分子はTTRを運動的に安定させ,アミロイドの形成を防止し,イメージングアプリケーションの可能性を秘めています.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...