関連する実験動画

Updated: May 9, 2026

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
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Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

TRF2媒介の染色体末端保護のための2段階メカニズム

Keiji Okamoto1, Cristina Bartocci, Iliana Ouzounov

  • 1Laboratory of Chromosome Biology and Genomic Stability, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

Nature
|February 8, 2013
PubMed
まとめ

テロメアタンパク質TRF2 (TERF2) は,染色体の末端を保護するために2段階のメカニズムを使用しています. まずATMの活性化を阻害し,その後下流のDNA損傷シグナリングを抑制し,融合を防ぐ.

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