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Updated: May 14, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
08:53

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

C9orf72 GGGGCCのリピートは,FTLD/ALSにおける二ペプチドリピートタンパク質の集積に変換される

Kohji Mori1, Shih-Ming Weng, Thomas Arzberger

  • 1Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Munich, Germany.

Science (New York, N.Y.)
|February 9, 2013
PubMed
まとめ

ファミリアルフロントテンポラルロバー変性およびALSの最も一般的な遺伝的原因であるC9orf72ヘクサヌクレオチドの繰り返し膨張は,特定のタンパク質の含有につながります. これらのインクルージョンにはディペプチドリピートタンパク質が含まれており,遺伝子変異を観察された病理学と直接関連付けています.

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