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Updated: May 14, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

細胞のLxxLLモチーフをパピローマウイルスE6のオンコプロテインによってハイジャックする構造的基礎

Katia Zanier1, Sebastian Charbonnier, Abdellahi Ould M'hamed Ould Sidi

  • 1Biotechnologie et Signalisation Cellulaire UMR 7242, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, BP 10413, F-67412 Illkirch, France.

Science (New York, N.Y.)
|February 9, 2013
PubMed
まとめ

パピローマウイルスE6のオンコタンパク質は,LxxLLモチーフを介して宿主タンパク質に結合することによって,上皮腫瘍を駆動する. 構造分析は,E6の腫瘍性活動と多機能性にとって重要な保存されたポケットを明らかにしています.

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