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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...

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Updated: May 14, 2026

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography
06:47

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography

Published on: August 25, 2023

歪んだアスピリン結晶.

Xiaoyan Cui1, Andrew L Rohl, Alexander Shtukenberg

  • 1Department of Chemistry, New York University, 100 Washington Square East, Silver Center, Room 1001, New York, New York 10003, United States.

Journal of the American Chemical Society
|February 22, 2013
PubMed
まとめ
この要約は機械生成です。

アスピリンをサリチル酸で結晶化すると,ユニークな帯状の球状石が生成されます. これらの構造は,分子張力によって駆動される,線形および円形の両方の二重断裂を持つヘリコイド結晶体を示します.

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

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ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography
06:47

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography

Published on: August 25, 2023

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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科学分野:

  • マテリアルサイエンス 材料科学
  • クリスタルグラフィーです.
  • ポリマーサイエンスの科学

背景:

  • スフェルーライトは,ポリマーや有機物質の一般的な結晶構造です.
  • アスピリン・サリチル酸システムの形成と性質を理解することは,医薬品の応用において極めて重要です.

研究 の 目的:

  • サリチル酸の存在下でのアスピリンの結晶化を調査する.
  • 形成された帯状球石の構造的および光学的性質を特徴づける.

主な方法:

  • 溶けたアスピリンの結晶化により,サリチル酸の濃度が変化します.
  • スキャニング電子顕微鏡 (SEM),X線微分法 (XRD),光学極測法を用いた分析.
  • 詳細な光学特性評価のためのミュラーマトリックスイメージング.

主要な成果:

  • <010>の成長方向に沿ってヘリコイド結晶石からなる帯状の球石が観察されました.
  • 線形と円形の両方のバイレフリンゲンスの半径振動が検出されました.
  • 光学現象の原因として,ラメラのわずかな,系統的なスプレーが特定されました.

結論:

  • 結晶体の歪みは,サリチル酸の組み込みによる分子ストレートに起因する.
  • 観測された光学特性は,結晶石の形態と組成と直接関連しています.
  • この研究は,有機結晶材料の構造-性質関係に関する洞察を提供します.