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Updated: Jul 25, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

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Published on: March 2, 2014

メジャーヒストコンパティビリティ複合体の遺伝子によって制御されるウイルス抗原のプレゼンテーション

V Cerundolo1, J Alexander, K Anderson

  • 1Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Nature
|May 31, 1990
PubMed
まとめ

研究者らは,メジャー・ヒストコンパティビリティ・コンプレックス (MHC) クラスI分子による細胞内ウイルス抗原の表現が低下した変異性ヒト細胞系 (LBL 721.174) を特定した. この欠陥は,染色体6に局在し,抗原関連に影響を及ぼし,ペプチド暴露によって部分的に回復することができます.

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Cell-mediated Immune Responses

Overview
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Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
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Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
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Cytomegalovirus Disease

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