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関連する概念動画

Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Updated: Apr 30, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 27, 2013

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TH17細胞の微分化を制御するダイナミックな規制ネットワーク.

Nir Yosef1, Alex K Shalek, Jellert T Gaublomme

  • 1Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|March 8, 2013
PubMed
まとめ
この要約は機械生成です。

研究者らは,マウスTH17細胞の分化を制御するダイナミックな規制ネットワークをマッピングした. この研究では,自己免疫疾患の39の調節因子と潜在的な薬物標的を特定しました.

さらに関連する動画

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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関連する実験動画

Last Updated: Apr 30, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 27, 2013

33.7K
Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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科学分野:

  • 免疫学 免疫学とは
  • システム生物学 システム生物学
  • コンピュータ生物学 コンピュータ生物学

背景:

  • ネイブT細胞の分化を制御する分子回路は,ほとんど知られていない.
  • 以前のレギュレータネットワークの研究は,短期的な反応に焦点を当て,プライマリT細胞には適していなかった.

研究 の 目的:

  • マウスTH17細胞の微分化のためのダイナミックな規制ネットワークモデルを体系的に導き,検証する.
  • TH17細胞に関連する自己免疫疾患の新たなレギュレータと潜在的な治療標的を特定する.

主な方法:

  • 高時間解像度の転写プロファイリング.
  • ネットワーク再構築のための新しい計算アルゴリズム.
  • 実験的検証のための革新的なナノワイヤベースのツール.

主要な成果:

  • マウスTH17細胞の分化のためのダイナミックな規制ネットワークモデルが確立されました.
  • 39の検証された要因のネットワーク内で12の新規規制者を特定しました.
  • ネットワークは,2つの自己強化し,相互に敵対するモジュールで構成されています.

結論:

  • 特定されたレギュレータの結合作用は,TH17および他のCD4 ((+)) T細胞サブセットのバランスをとる上で極めて重要です.
  • この研究は,TH17転写ネットワークの組織原理を明らかにしています.
  • TH17細胞の分化制御のための新薬標的が強調されました.