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Updated: May 13, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

アロステル活性化剤によるSIRT1調節の一般的なメカニズムの証拠

Basil P Hubbard1, Ana P Gomes, Han Dai

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|March 9, 2013
PubMed
まとめ

サーチューイン活性化化合物 (STAC) は,その基板の水嫌性モチーフと相互作用することによってSIRT1を活性化します. SIRT1内の特定のグルタミン酸残留は,この活性化に不可欠であり,多様なSTACsの共通のアロステリックメカニズムを明らかにします.

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