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女性における喫煙,手術,静脈血栓塞栓症のリスク: イギリスのコホート研究
Siân Sweetland1, Lianne Parkin, Angela Balkwill
1Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom. sian.sweetland@ceu.ox.ac.uk
Circulation
|March 14, 2013
まとめ
喫煙は,一般的に,そして手術後の女性において,静脈血栓塞栓症 (VTE) のリスクを高めます. 現在の喫煙者は,決して喫煙していない人と比較して,VTEのより高い発生率に直面しており,喫煙を主要なリスク要因として強調しています.
科学分野:
- 医学研究 医学研究
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 静脈血栓栓塞栓症 (VTE) リスクに対する喫煙の影響に関する限られた不一致な証拠が存在する.
- 喫煙がVTEに与える影響は,特に手術後の期間に,さらなる調査が必要である.
研究 の 目的:
- 喫煙習慣に関連したVTEの発生率を調べる.
- 手術が行われていない場合と,手術後の最初の12週間の間におけるVTEリスクを評価する.
主な方法:
- イギリスの100万人以上の女性を対象とした大規模な見通し調査です.
- VTE入院または死亡を記録するために6年以上の追跡調査.
- 喫煙状況 (現在の喫煙者 vs. 未喫煙者) と喫煙の強度に基づいてVTE発生率の分析.
主要な成果:
- 喫煙者のVTE発症率は,喫煙しない人よりもかなり高かった (調整された相対リスク1.38).
- VTEのリスクは,喫煙の強度 (≥15タバコ/日 vs. <15タバコ/日) により増加しました.
- 最初の12週間の術後のVTE発生率は,現在の喫煙者でも著しく高かった.
結論:
- 喫煙は,手術状態に関係なく,VTE発生率の増加と関連しています.
- この発見は,特に外科手術を受けた患者の場合,VTEの評価において喫煙を重要な危険因子として考慮することの重要性を強調しています.
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