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Updated: Jan 30, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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HNF-4α核受容体複合体の構造における多領域統合

Vikas Chandra1, Pengxiang Huang, Nalini Potluri

  • 1Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA.

Nature
|March 15, 2013
PubMed
まとめ

ヘパトサイト核因子4α (HNF-4α) 構造は,変異が糖尿病を引き起こす方法を明らかにします. 翻訳後の改変とドメイン接続はDNA結合に影響を与え,代謝疾患の新たな治療標的を提供している.

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