オーガニック・ミトラル反吐における右心房シストリック機能:二心房機能障害の影響
Thierry Le Tourneau1, Guillaume Deswarte, Nicolas Lamblin
1Inserm, UMR 1087, Institut du thorax, Nantes, France. thletourneau@yahoo.fr
Circulation
|March 15, 2013
まとめ
右心室放出分数 (EF) 障害は,オーガニック・ミトラル反発で一般的であり,左心室の問題と関連しています. RV機能の障害は,特に双心房機能不全の場合,長期生存に重大な影響を及ぼします.
科学分野:
- 心臓病学 心臓病学
- 心臓画像検査 (Cardiac Imaging) について
- 心不全による心不全.
背景:
- 右心室 (RV) の放出分数 (EF) の障害は,有機的ミトラル吐における重要な懸念事項である.
- RV EFの有病率,決定因子,および予後値の評価は,患者管理において極めて重要です.
研究 の 目的:
- オーガニック・ミトラル反吐の患者におけるRV放出分数 (EF) 障害の有病率,決定因子,および予後的意義を評価する.
- RV機能障害が心血管や全生存期に与える影響を調査する.
主な方法:
- エコカルディオグラフィとビブントリキュラー放射性核素血管図は,慢性的な有機ミトラル吐症の208人の患者に実施されました.
- 地域機能評価と,左心室機能と肺動脈静脈圧を含む病理生理学的相関体の分析.
- 長期心血管疾患および全生存率は,RV EFと双心室機能障害に関連して分析されました.
主要な成果:
- RVEFの平均値は40.4±10.2%で,30%の患者で重度の障害 (≤35%) が認められた.
- RV EFは,主に左心室隔膜機能,終盤動脈直径,肺動脈静脈圧によって決定された.
- RV EFは,初期うつ病 (P<0.0001) の患者に手術後の症状を有意に改善しました.
- RV EF ≤35% 低下した10年心血管生存率 (71.6% vs 89.8%,P=0.037)
- バイブントリキュラー機能障害は,10年間の心血管疾患 (51.9%対90.3%,P<0.0001) と全生存率 (34.8%対72.6%,P=0.003) を劇的に減少させた.
結論:
- 右心室の機能障害は,主として左心室の改造と隔膜機能の影響を受け,有機的ミトラル反発では頻繁です.
- RV機能は,手術後の心血管生存の予測要因として機能します.
- 双動脈障害は,この患者コホートにおける心血管疾患および全生存率の両方の強力な予測因子です.
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