肺高通胀と左心室質量:動脈硬化症の多民族研究 COPDの研究
Benjamin M Smith1, Steven M Kawut, David A Bluemke
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Circulation
|March 16, 2013
まとめ
慢性閉塞性肺疾患 (COPD) の残留肺容量の増加は,左心室 (LV) 質量の増加と関連しています. この発見は,COPD患者における肺の膨張に関連した潜在的心血管リスクを強調しています.
科学分野:
- 心臓病学 心臓病学
- 肺内科 肺内科 肺内科
- メディカルイマージング (医学イメージング)
背景:
- 左心室 (LV) 質量は,心不全と心血管疾患による死亡率の重要な予測因子です.
- LV質量の決定因子は完全に理解されていません.
- 慢性閉塞性肺疾患 (COPD) の肺高膨胀は胸内圧を変化させ,LV壁のストレスを増加させる可能性があります.
研究 の 目的:
- COPDにおける残留肺体積とLV質量との関連を調査する.
主な方法:
- 動脈硬化症の多民族研究 (MESA) COPD研究には,臨床心血管疾患のない50〜79歳の喫煙者が含まれていました.
- LV質量は心臓磁気共鳴画像を用いて定量化されました.
- 肺機能検査で肺の体積が測定され,共変数に調整されたリグレッションモデル.
主要な成果:
- 119人の参加者 (65%がCOPD患者) のうち,残留肺容量は独立して,より大きなLV質量 (1-SD増加あたり7.2g,P=0.004) と関連していました.
- この関連性は,シストリック血圧の大きさに匹敵していました.
- 同様の関連性は,LV質量と終結ダイアストリック体積の比率,および残留体積と肺総容量の比率にも見られた.
結論:
- 余分な肺容量または余分な肺容量と全肺容量の比率によって示される肺ハイパーインフレーションは,LVマスの増加と関連しています.
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