転写の調節と病気における誤調節
Tong Ihn Lee1, Richard A Young
1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Cell
|March 19, 2013
まとめ
遺伝子発現プログラムは,ヒトの細胞状態を制御する. 転写因子やレギュレータによってこれらのプログラムが誤って調節されると,病気を引き起こす可能性があり,最近の進歩は新しい洞察を提供している.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
- 細胞生物学 細胞生物学
背景:
- 人間の細胞のアイデンティティは,複雑な遺伝子発現プログラムに依存しています.
- 何千もの転写因子,共因子,染色体調節剤がこれらのプログラムを編成する.
- 遺伝子発現の調節不全は,様々なヒト疾患と関連しています.
研究 の 目的:
- 転写制御の理解における最近の進歩をレビューする.
- 病気におけるトランスクリプションの誤調に関する洞察を探求する.
主な方法:
- 転写調節に関する最近の研究に関する文献レビュー.
- 遺伝子発現の誤調を病気と結びつける研究を分析する.
主要な成果:
- 転写調節のメカニズムを解読するうえで,著しい進展がみられた.
- 新しい理解は,疾患の病原化に関与する特定の経路と要因を強調しています.
- このレビューは,疾患のスペクトルにおける転写不調の役割に関する現在の知識を統合しています.
結論:
- 転写制御研究における進歩は,疾患のメカニズムに関する重要な洞察を提供します.
- トランスクリプションの誤調をターゲットにすることは,様々な疾患に対する潜在的な治療戦略を提供します.
- 遺伝子の発現エラーに関連した疾患を完全に理解し,それと闘うためには,継続的な研究が不可欠です.
関連する概念動画
02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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02:24Regulation of Expression Occurs at Multiple Steps
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
01:23Regulation of Expression at Multiple Steps
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01:29Translational Regulation
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