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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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関連する実験動画

Updated: May 13, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

長いノンコーディングRNA: 発達と疾患における細胞アドレスコード

Pedro J Batista1, Howard Y Chang

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|March 19, 2013
PubMed
まとめ
この要約は機械生成です。

長いノンコーディングRNA (lncRNAs) は,細胞のアドレスコードとして作用し,分子や遺伝子を正しい位置に導きます. この正確な核組織は,細胞の発達と遺伝的異常に関連した病気の予防に不可欠です.

さらに関連する動画

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

関連する実験動画

Last Updated: May 13, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • 細胞生物学 細胞生物学

背景:

  • 核の組織は,不動産の位置に似ているように,生物学的プロセスにとって根本的なものです.
  • 原子核内の分子および遺伝的要素の"アドレスコード"を理解することは,重要な研究問題である.
  • 長いノンコーディングRNA (lncRNAs) は,細胞組織における役割としてますます認識されています.

研究 の 目的:

  • 核アドレスコードの構成要素としての lncRNA の役割を明らかにする.
  • lncRNAsが細胞構成要素の密輸と調節をどのように促進するのかを調査する.
  • lncRNAの機能が発達や病気に及ぼす影響を調査する.

主な方法:

  • この研究は,核組織における lncRNA の機能的メカニズムに焦点を当てています.
  • lncRNAsがタンパク質複合体,遺伝子,染色体の局所化をどのように媒介するかを研究しています.
  • lncRNA不調と染色体異常との関連を検証する.

主要な成果:

  • lncRNAは核アドレスコードの重要な要素として機能する.
  • これらの分子は,細胞の構成要素の適切な配置と回収を指示する.
  • lncRNAベースのメカニズムは,発達中の細胞運命を制御するために不可欠です.
  • lncRNAsの調節不良は,染色体変異を含むヒト疾患に関与しています.

結論:

  • lncRNAは,核組織と細胞機能の重要な調節体である.
  • 密輸と局所化における彼らの役割は,正常な発達に不可欠です.
  • 異常な lncRNA 活動は遺伝的疾患や疾患に寄与する.