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Updated: May 13, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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SCF ((FBXL3) ユビキチンリガゼは,コファクターポケットにある暗号クロモスを標的とする

Weiman Xing1, Luca Busino, Thomas R Hinds

  • 1Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA.

Nature
|March 19, 2013
PubMed
まとめ

哺乳類のクリプトクローム2 (CRY2) 構造は,FBXL3がCRY2を分解するようにターゲットを設定し,昼夜時計に影響を与えることを明らかにしています. この相互作用は,フラビンアデニンジヌクレオチド (FAD) とペリオドタンパク質 (PERs) によって影響を受け,潜在的な薬物標的を提供している.

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