妊娠中の母親のビタミンD状態と子孫の骨ミネラル含有量の関連:前向きなコホート研究
Debbie A Lawlor1, Andrew K Wills, Abigail Fraser
1MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol UK. d.a.lawlor@bristol.ac.uk
Lancet (London, England)
|March 23, 2013
まとめ
妊娠中の母親のビタミンDレベルは,幼児期の末期の子孫の骨のミネラル含有量に影響を与えませんでした. この大規模な研究では,母親の25~OH) D状態と子供の骨の健康との間に有意な関連性が見つかりませんでした.
科学分野:
- 人間の生理学 人間生理学
- 栄養科学とは,栄養科学である.
- 小児の健康に関する小児保健
背景:
- 妊娠中の母親のビタミンDの状態は,子孫の骨のミネラル含有量 (BMC) に影響すると仮定されています.
- この関連性に関する以前の研究は,小規模な研究によって制限されていた.
- この研究は,大規模な前向きなコホートにおけるリンクを調査しています.
研究 の 目的:
- 妊娠中の母親の血清25-ヒドロキシビタミンD [25(OH) D]濃度と9〜10歳の子孫のBMCとの関連を調べる.
- 異なる三半期における母親のビタミンD状態が子孫の骨の発達に影響するかどうかを判断する.
主な方法:
- 3960組の母子ペアを含む,親子に関するアヴォン長期研究 (Avon Longitudinal Study of Parents and Children) のデータを活用した.
- 妊娠中と出産後の母親の25 (OH) D濃度,頭抜き全身 (TBLH) と脊髄 BMCを二重エネルギーX線吸収計で測定した.
- 十分な (>50.00 nmol/L),不十分な (27.50-49.99 nmol/L),または欠乏的な (<27.50 nmol/L) として分類された母性25(OH) D.
主要な成果:
- 十分なビタミンDレベル,不十分なビタミンDレベル,または欠乏したビタミンDレベルを持つ母親の子孫の間では,TBLHまたは脊髄BMCの有意な違いは観察されなかった.
- 第3 trimesterを含む妊娠3ヶ月間の分析は,子孫のBMCとの関連性がないことを明らかにしました.
- TBLHと脊髄BMCの混同調整平均差は,母体25~OH) Dの10.0nmol/L増加あたりの差は軽微であった.
結論:
- 妊娠中の母親のビタミンD状態は,幼児期の末期の子孫の骨のミネラル含有量の重要な決定因子ではありません.
- これらの発見は,子供の骨の健康を改善するために,母親のビタミンDにのみ焦点を当てた介入が効果的ではないことを示唆しています.
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