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Updated: May 12, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

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Published on: March 7, 2017

小児の膠芽細胞腫で発見された機能獲得H3変異によってPRC2の活性が抑制される

Peter W Lewis1, Manuel M Müller, Matthew S Koletsky

  • 1Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.

Science (New York, N.Y.)
|March 30, 2013
PubMed
まとめ

ヒストンH3 Lys27Met (K27M) 変異を有する小児性膠質腫では,H3K27me3のレベルが低下しています. このK27M変異はポリコンブ抑制複合体2を阻害し,がんにおける新たな表遺伝子変化メカニズムを示唆している.

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