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関連する概念動画

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...

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Updated: May 12, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
07:08

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

がんにおける表皮遺伝的再プログラミング

Mario L Suvà1, Nicolo Riggi, Bradley E Bernstein

  • 1Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Science (New York, N.Y.)
|March 30, 2013
PubMed
まとめ

転写因子とクロマチンの調節因子によって引き起こされる細胞状態の移行は,がんの発達と幹細胞モデルについての洞察を提供します. これらのメカニズムを理解することは,再生医療と腫瘍学の鍵です.

科学分野:

  • 細胞生物学 細胞生物学
  • エピジェネティクス エピジェネティクス
  • 腫瘍学 腫瘍学

背景:

  • 誘導された多能性および直接系統変換は,細胞状態の移行における転写因子とクロマチンの調節体の役割を明らかにする.
  • これらのプロセスは,再生医療と癌の発達を理解するための意味を持っています.

研究 の 目的:

  • 細胞状態の移行と腫瘍生成の間の概念的なパラレルを見直す.
  • 転写因子,クロマチンの調節因子,がんにおける表遺伝的状態の相互関係を強調する.

主な方法:

  • 文献レビューと概念分析.
  • 細胞再プログラムとがん生物学におけるメカニズムの比較分析.

主要な成果:

  • 転写因子,クロマチンの調節体,表遺伝子状態を含む共有メカニズムが特定される.
  • これらの共有経路は,腫瘍的変異と腫瘍の異質性を明らかにします.

結論:

  • 細胞状態移行メカニズムの理解は,がん幹細胞モデルへの洞察を提供します.
  • 発見は,共通の規制原則を強調することによって,再生医療とがん研究を橋渡ししています.

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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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関連する実験動画

Last Updated: May 12, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018