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ZMPSTE24依存型ラミノパシーの構造的基礎

Andrew Quigley1, Yin Yao Dong, Ashley C W Pike

  • 1Structural Genomics Consortium, University of Oxford, Oxford, UK.

Science (New York, N.Y.)
|March 30, 2013
PubMed
まとめ

ZMPSTE24の変異は,プレラミンAの処理を妨害することで,ラミノパシーを引き起こす. 構造分析は,突然変異が酵素活性と病気にどのように影響するかを明らかにします.

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