癌のゲノムとエピゲノムの相互作用
1USC Epigenome Center, University of Southern California, Room G511B, 1450 Biggy Street, Los Angeles, CA 90089-9061, USA.
Cell
|April 2, 2013
まとめ
癌は,細胞に成長の優位性を与える累積された遺伝的および表遺伝的変化を伴う. この研究では,ゲノムとエピゲノムの変化がどのように協力してがんの発症を促すかを調査しています.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- 癌は,細胞の成長制御の累積的な障害から発症する.
- 遺伝的変化によってクローン上の優位性が得られることが,がんの進行過程で選択される.
- これらの特徴は,遺伝的または表遺伝的変化によって得られます.
研究 の 目的:
- ガンにおけるゲノムとエピゲノム変化の相互作用を探求する.
- これらの変化がどのように協力して腫瘍性変異を促進するのかを理解する.
主な方法:
- 癌遺伝学と表遺伝学に関する既存の研究のレビューと合成.
- 遺伝的および表遺伝的変異が相互に影響するメカニズムの分析.
主要な成果:
- ゲノムとエピゲノムの変異は独立していないが,がんの発症に協力している.
- エピゲノム制御の障害は悪性腫瘍の共通の特徴である.
- エピジェノミック破壊は,がん細胞の有効な特徴として作用します.
結論:
- 遺伝的および表遺伝的変化の相互作用は,腫瘍性変異に不可欠である.
- エピジェネティック不調は,ゲノム不安定に匹敵する,癌の根本的な側面です.
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