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Updated: May 12, 2026

Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts
07:02

Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts

Published on: May 11, 2018

シノビア・サルコマにおけるSS18-SSX腫瘍性融合によるmSWI/SNF (BAF) 複合体の可逆的な破壊

Cigall Kadoch1, Gerald R Crabtree

  • 1Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|April 2, 2013
PubMed
まとめ

SWI/SNF (BAF) 複合体の変異は,ヒトのがんではよく見られる. シノヴィアル・サルコマでは,SS18-SSX融合タンパク質がBAF複合体を破壊し,Sox2遺伝子を活性化し,腫瘍の成長を促します.

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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