メラトニンの分泌と2型糖尿病の発生率
Ciaran J McMullan1, Eva S Schernhammer, Eric B Rimm
1Renal Division, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. cmcmullan1@partners.org
JAMA
|April 4, 2013
まとめ
メラトニンの分泌量の低下は,2型糖尿病のリスクの増加と関連しています. この研究では,メラトニンが少ない女性は,糖尿病を発症する可能性が著しく高かったことがわかりました.
科学分野:
- エンドクリノロジー エンドクリノロジー
- メタボリック・ヘルス (代謝の健康)
- クロノバイオロジーはクロノバイオロジーを用います.
背景:
- メラトニン受容体の機能喪失変異は,インスリン抵抗性および2型糖尿病と関連しています.
- 夜間メラトニンの低分泌は,糖尿病のない人のインスリン抵抗性の増加と相関しています.
研究 の 目的:
- メラトニン分泌レベルと,その後の2型糖尿病の発症リスクとの関連を調査する.
主な方法:
- 看護師の健康研究コホートの中でケース・コントロール研究が行われました.
- 2000年から2012年の間に2型糖尿病を発症した370人の女性と,糖尿病のない370人の対照群を2000年からの尿と血液サンプルに基づいてマッチングした.
- 多変量条件ロジスティック回帰は,さまざまな人口,ライフスタイル,睡眠の質,炎症,内皮機能不全の要因を制御して,関連を分析するために使用されました.
主要な成果:
- 尿中の6-スルファトキシメラトニンとクレアチニンの比率が低い女性は,2型糖尿病のリスクが増加しました.
- 2型糖尿病を発症させる多変数確率比は,最も低いメラトニン分泌のカテゴリーに属する女性では2.17 (95%CI,1.18-3.98) であった.
- 糖尿病の発生率は,メラトニン分泌量が最も高いグループでは4.27例/1000人/年,最も低いグループでは9.27例/1000人/年であった.
結論:
- メラトニンの分泌量の減少は,2型糖尿病を発症するリスクの上昇と独立して関連しています.
- メラトニン分泌が一般の人々の2型糖尿病の修正可能な危険因子であるかどうかを判断するためのさらなる研究が推奨されています.
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