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白血病細胞における変異性IDH2の標的型阻害は,細胞の分化を引き起こします

Fang Wang1, Jeremy Travins, Byron DeLaBarre

  • 1Agios Pharmaceuticals, Cambridge, MA 02139-4169, USA.

Science (New York, N.Y.)
|April 6, 2013
PubMed
まとめ

新しい小分子であるAGI-6780は,特定の癌の主要な要因である変異性イソシトラート脱水素酵素2 (IDH2/R140Q) を選択的に抑制します. この標的型阻害は,がん治療における差別化療法の可能性を示している.

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