BRAF V600E変異とパピラリ甲状腺がん患者の死亡率との関連
Mingzhao Xing1, Ali S Alzahrani, Kathryn A Carson
1Laboratory for Cellular and Molecular Thyroid Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. mxing1@jhmi.edu
JAMA
|April 11, 2013
まとめ
BRAF V600E変異は,パピラリ甲状腺がん (PTC) の死亡率の増加と関連しています. しかし,この関連性は腫瘍の特徴とは無関係ではないため,BRAF V600Eのさらなる研究が必要であることを示唆しています.
科学分野:
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
- 病理学 パトロジー
背景:
- BRAF V600E腫瘍遺伝子は,パピラリ甲状腺がん (PTC) で一般的です.
- PTC特異的な死亡率に関連したBRAF V600E変異の予後的意義は不明である.
研究 の 目的:
- BRAF V600E変異とパピラリ甲状腺がん患者の死亡率との関連を調査する.
主な方法:
- 7カ国の13のセンターから1,849人のPTC患者が参加したレトロスペクティブ研究です.
- データは1978年から2011年の間に収集され,追跡期間の中央値は33ヶ月でした.
- PTCに関連した死亡が主なアウトカムメーターでした.
主要な成果:
- BRAF V600E陽性患者は,変異陰性患者 (1.1%) と比較して,PTC関連の死亡率 (5.3%) が著しく高かった.
- BRAF V600E陽性患者の死亡率に対する調整された危険比率は,すべてのPTCで2.66であり,従来の変種では3.53であった.
- この関連性は,転移や侵入などの腫瘍特性を調整すると,統計的有意性を失いました.
結論:
- BRAF V600E変異は,PTC関連の死亡率の増加と関連しています.
- しかし,その関連性は腫瘍の特徴とは無関係ではなく,死亡リスク管理におけるその役割については,さらなる調査が必要である.
- これらの発見は,PTCにおけるBRAF V600E状態の予後および治療上の影響に関するさらなる研究の必要性を強調しています.
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