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Updated: May 12, 2026

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
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キヌレニン3-モノオキシゲネーゼ抑制の構造的基礎

Marta Amaral1, Colin Levy, Derren J Heyes

  • 1Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Nature
|April 12, 2013
PubMed
まとめ

キヌレニン3-モノオキシゲナーゼ (KMO) の抑制は,神経変性疾患の治療の可能性を示しています. KMOの最初の結晶構造は,阻害剤が結合する方法を明らかにし,アルツハイマー病やパーキンソン病などの疾患に対する構造ベースの薬剤設計を可能にします.

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