病気と薬物の発見におけるアロステリー
Ruth Nussinov1, Chung-Jung Tsai
1National Cancer Institute, Center for Cancer Research Nanobiology Program, Frederick National Laboratory for Cancer Research, SAIC-Frederick, Inc., National Cancer Institute, Frederick, MD 21702, USA. nussinor@helix.nih.gov
Cell
|April 16, 2013
まとめ
アロステリーは,形状の変化を通してタンパク質の機能を調節し,細胞のプロセスや病気に影響を与えます. 異常なアロステリック作用を理解することは,革新的なアロステリック薬の開発の可能性を提供します.
科学分野:
- バイオケミストリー バイオケミストリー
- 分子生物学は分子生物学である.
- 薬理学 薬理学とは
背景:
- アロステリーは,伝統的に個々のタンパク質内の構造的および機能的変化を記述しています.
- アロステリーの概念は,タンパク質の構成の変化の影響を受ける細胞機能と疾患状態に及ぶ.
研究 の 目的:
- アロステリーの概念とその生理学的活動に対するコントロールを明確にすること.
- アロステル系メカニズムが病気の因果関係にどのように寄与するかを探求する.
- 革新的な薬の開発のためのアロステリック経路をターゲットにすることの治療的可能性を強調する.
主な方法:
- アロステル調節の概念的明確化.
- 細胞疾患の症状と分子アロステリック不調の間の関連性の分析.
- アロステリック薬の開発戦略のレビュー.
主要な成果:
- アロステリックメカニズムは,生理学的活動の重要な調節体である.
- 分子レベルで異常なアロステル作用は,細胞疾患の症状と関連しています.
- アロステリック調節は,新しい治療介入のための有望な道を示しています.
結論:
- アロステリーのより深い理解は,病気のメカニズムを理解するために不可欠です.
- アロステル経路をターゲットにすることは,革新的な治療法の開発に重要な可能性を秘めています.
- 分子アロステリックイベントと細胞病理の間のギャップを埋めることは,将来の薬剤発見の鍵です.
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