小児の片頭痛と乳児コリックの歴史との関連性
Silvia Romanello1, Daniele Spiri, Elena Marcuzzi
1Department of Pediatric Emergency Care, APHP-Hospital Robert Debré, Paris, France.
JAMA
|April 18, 2013
まとめ
片頭痛と診断された子供は,乳幼児コリックの病歴を持つ可能性が著しく高かった. これは,小児の集団における早期の痛みと後の片頭痛の発達との潜在的な関連を示唆しています.
科学分野:
- 小児神経学について
- 痛み症候群 痛み症候群について
- エピデミオロジー エピデミオロジー
背景:
- 乳児コリックは,乳児の慰められない泣き声を引き起こす一般的な状態で,しばしば疼痛症候群として認識されます.
- 片頭痛は,子供の頃の頭痛の痛みの一般的な原因です.
- 乳児コリックと小児性片頭痛の潜在的関連性は,未知のままです.
研究 の 目的:
- 乳幼児のコリックと小児期の片頭痛の発症との関連性を調査する.
- 乳児コリックの病歴が,片頭痛と診断された子供ではより一般的かどうかを判断する.
主な方法:
- 症例対照研究では,片頭痛と診断された208人の子供 (6歳から18歳) と,軽度のトラウマを呈した471人のコントロール (6歳から18歳) が参加しました.
- 乳児コリック歴に関するデータは,構造化されたアンケートを通じて収集され,保健小冊子で確認されました.
- 2次研究では,緊張型頭痛の子ども120人を対象に,観察された関連性の特異性を評価した.
主要な成果:
- 片頭痛を患っている子どもは,対照群 (26.5%) と比較して,乳幼児コリック歴 (72.6%) の有意に高い罹患率を示し,その確率比率は6.61 (95%CI,4.38-10.00) であった.
- この関連性は,オーラのある片頭痛とオーラのない片頭痛の両方のサブタイプに一貫していました.
- 幼児コリックと緊張型頭痛 (OR,1.46;P = .10) の間に有意な関連性が見つかりませんでした.
結論:
- 乳児コリックの病歴は,子どもおよび青少年における片頭痛の存在と有意に関連しています.
- この発見は,幼児期の痛みの経験と後期の片頭痛の発症との間に潜在的な関連があることを示唆している.
- この関連性を確認し,根本的なメカニズムを探求するために,さらなる縦断的な研究が必要である.
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