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Updated: May 12, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

障害のあるα-TTP-PIPsの相互作用が,家族性ビタミンE欠乏症の基礎となっている

Nozomu Kono1, Umeharu Ohto, Tatsufumi Hiramatsu

  • 1Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.

Science (New York, N.Y.)
|April 20, 2013
PubMed
まとめ

フォスファディチルニノシトールリン酸塩 (PIP) はアルファトコフェロール (ビタミンE) 転送タンパク質 (α-TTP) に結合し,ビタミンEの分泌を促進します. この結合はα-TTPのリガンド結合ポケットを開き,ビタミンE欠乏におけるアルギニン残留物の役割を明らかにする.

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