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Updated: May 12, 2026

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
09:19

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization

Published on: March 16, 2020

前活性化されたアリストリンp44の結晶構造

Yong Ju Kim1, Klaus Peter Hofmann, Oliver P Ernst

  • 1Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

Nature
|April 23, 2013
PubMed
まとめ

Gタンパク質結合受容体 (GPCR) のシグナル伝達に不可欠なアレスティンの活性化には,C尾の移位が含まれています. この研究は,事前活性化されたアレスチン構造を明らかにし,重要な形状の変化と新しい活性化メカニズムを発見しました.

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