関連する実験動画

Updated: May 12, 2026

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

活性β-アレスティン-1がGタンパク質結合受容体フォスホペプチドに結合する構造

Arun K Shukla1, Aashish Manglik, Andrew C Kruse

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nature
|April 23, 2013
PubMed
まとめ

研究者らは,活性化されたβ-アレスティン-1 (アレスティン-2) がリン酸化V2バソプレシン受容体ペプチドに結合する高解像度構造を明らかにした. この構造は,β-アレステンの活性化メカニズムと,Gタンパク質結合受容体 (GPCR) 信号伝達の受容体相互作用を明確にします.

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