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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

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Updated: May 12, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

プログラム可能なアクティブリリースのポリマーマイクロカプセル.

Alireza Abbaspourrad1, Nick J Carroll, Shin-Hyun Kim

  • 1School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|April 24, 2013
PubMed
まとめ
この要約は機械生成です。

私たちは,調整可能な貨物放出機能を備えた活性放出マイクロカプセルを開発しました. このメカニズムは,弾性刺激を用いて,急速な爆発から持続的な放出までの放出運動を制御する.

さらに関連する動画

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

関連する実験動画

Last Updated: May 12, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

科学分野:

  • 材料科学 材料科学とは
  • ポリマーサイエンスの科学
  • 化学工学は化学工学というものです.

背景:

  • マイクロカプセルは,活性物質をカプセル化および投与するために広く使用されています.
  • 封装された材料の放出率を制御することは,多くの用途において極めて重要です.
  • 既存の放出メカニズムは,しばしば,漁獲能力と正確な制御が欠けている.

研究 の 目的:

  • アクティブで調節可能なリリースメカニズムを備えた新しいマイクロカプセルシステムを導入する.
  • 膜流動性を調節することにより,放出運動学に対する制御を実証する.
  • 異なるポリマーシステムにおけるこの活性放出アプローチの汎用性を探求する.

主な方法:

  • マイクロフリウイドアプローチを用いたマイクロカプセル製造.
  • ポリマー膜における相変化変遷の誘導は,可塑性刺激を用いて行われます.
  • 刺激濃度,ポリマーの分子量,膜の厚さを調整することで,放出運動を調節する.

主要な成果:

  • サブセカンドバーストリリースから数分間にわたる持続的なリリースまで,調節可能なリリースの動力学を達成しました.
  • 集団カプセルトリガー反応に対する実証されたコントロール.
  • ポリスチレンとゴムのようなブロックコポリマーカプセルに活性放出メカニズムを成功裏に適用しました.

結論:

  • 開発されたマイクロカプセルシステムは,制御された貨物放出のための汎用性のあるプラットフォームを提供します.
  • アクティブリリースのメカニズムは,リリースの運動を時間的に正確に制御します.
  • この技術は,制御された配送を必要とするさまざまな実用的なアプリケーションに重要な可能性を秘めています.