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Mg2+はチミジラート合成酵素の表面に結合し,内部活性部位の水素移転に影響を与えます

Zhen Wang1, Paul J Sapienza, Thelma Abeysinghe

  • 1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.

Journal of the American Chemical Society
|April 25, 2013
PubMed
まとめ

マグネシウムイオン (Mg2+) は,チミジラート合成酵素 (TSase) の表面に結合し,その構造を安定させ,DNA合成を7倍加速します. この長距離相互作用は酵素の活性に影響を与え,新しい薬剤の設計を導く.

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