ヒトパピローマウイルスと子宮頸がん
Emma J Crosbie1, Mark H Einstein, Silvia Franceschi
1Institute of Cancer Sciences, University of Manchester, Oxford Road, Manchester, UK.
Lancet (London, England)
|April 27, 2013
まとめ
持続的な高リスクヒトパピローマウイルス (HPV) 感染症は,様々な癌を引き起こす. HPVワクチンと検査は,世界中で命を救える重要な予防戦略です.
科学分野:
- 腫瘍学 腫瘍学
- ウイルス学 ウイルス学 ウイルス学
- 公衆衛生は公衆衛生である.
背景:
- 子宮頸がんは,主に高リスクヒトパピローマウイルス (HPV) 感染症,特にHPVタイプ16の持続的な感染によって引き起こされます.
- HPVは上皮細胞に感染し,細胞サイクル制御を妨害し,制御不能の細胞分裂と遺伝的損傷につながります.
研究 の 目的:
- 癌発症におけるヒトパピローマウイルス (HPV) の役割を検討する.
- 癌予防戦略における予防ワクチンとHPV検査の重要性を強調する.
主な方法:
- HPV感染,病原性,予防に関する既存の文献のレビュー.
- 1次および2次予防におけるHPVワクチンおよびHPV検査の臨床的有用性の分析.
主要な成果:
- 2つの効果的な予防HPVワクチン (HPV 16/18とHPV 16/18/6/11) が利用可能であり,先進国では使用されています.
- HPV検査は,二次予防,細胞分類,治療のテストとして,細胞学よりも高い感度を提供し,スクリーニング間隔を延長することを可能にするため,価値があります.
結論:
- 予防的なHPVワクチン接種とHPV検査は,HPV関連がんに対する主要な一次および二次予防戦略です.
- 開発途上国におけるこれらの予防戦略の実施は,多くの命を救う可能性を秘めています.
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