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関連する概念動画

Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...

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関連する実験動画

Updated: May 11, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

マイクロRNAはERを訪問する.

Taiowa A Montgomery1, Gary Ruvkun

  • 1Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.

Cell
|April 30, 2013
PubMed
まとめ
この要約は機械生成です。

植物マイクロRNA (miRNA) は,現在,エンドプラズマ網膜内の遺伝子標的を調節することが知られている. この研究は,遺伝子サイレンシングに関与する植物ミRNA経路の新しい成分を特定しています.

さらに関連する動画

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

関連する実験動画

Last Updated: May 11, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

科学分野:

  • 分子生物学は分子生物学である.
  • 植物科学 植物科学について
  • 遺伝学 遺伝学とは

背景:

  • マイクロRNA (miRNA) は,真核生物における遺伝子発現の重要な調節因子である.
  • miRNA媒介の遺伝子サイレンシングの正確な細胞下局部化は,多くの経路ではほとんど不明のままである.
  • miRNA標的の調節を理解することは,遺伝子発現制御の解読の鍵です.

研究 の 目的:

  • マイクロRNA (miRNA) がその調節機能を果たす細胞の位置を調査する.
  • 植物ミRNA経路に関与する新しい成分を特定する.
  • miRNA媒介による遺伝子サイレンシングにおける特定の臓器細胞の役割を明らかにする.

主な方法:

  • 植物におけるmiRNAの活性について研究するために,高度な分子生物学技術を活用した.
  • miRNA経路の成分と細胞臓器の相互作用を調査した.
  • 機能的役割を確認するために,遺伝子サイレンシングアッセイを採用した.

主要な成果:

  • 植物ミRNA経路に関与する新しいタンパク質を特定しました.
  • エンドプラズマ網膜がmiRNA媒介による遺伝子サイレンシングの場であることを実証した.
  • この過程におけるエンドプラズマ網膜の機能的重要性を証明した.

結論:

  • エンドプラズマの網膜は,植物のmiRNA媒介による遺伝子サイレンシングにおいて重要な役割を果たします.
  • この発見は,miRNA活動の細胞下局部化についての理解を広げています.
  • 植物の転写後の遺伝子調節に関する研究のための新しい道を開く.