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Updated: May 11, 2026

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening
09:49

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

Published on: November 20, 2018

ハイドロフォビックな表面は,タウタンパク質由来ヘキサペプチドの集積を抑制するために不可欠です

Jing Zheng1, Arya M Baghkhanian, James S Nowick

  • 1Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States.

Journal of the American Chemical Society
|May 1, 2013
PubMed
まとめ

マクロサイクリックペプチドは,水害性の表面をターゲットにすることで,タウタンパク質の結合を阻害する. 特定の残基変異は,アミロイドの形成を防ぐために不可欠な重要な水害性相互作用を明らかにします.

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