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Updated: May 11, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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ダイアステロエーマー型スピロオキシンドールは,非常に強力で効果的なMDM2阻害剤である

Yujun Zhao1, Liu Liu, Wei Sun

  • 1Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA.

Journal of the American Chemical Society
|May 7, 2013
PubMed
まとめ

研究者らは,がん治療に不可欠なMDM2-p53相互作用を阻害する新しいスピロキシンドール化合物を発見しました. 立体化学は効力に大きく影響し,動物モデルで腫瘍の完全な回帰を引き起こした非常に効果的な阻害剤 (MI-888) に繋がります.

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