尿血における塩と水分保持とカルシウム阻害
G M London1, S J Marchais, A P Guerin
1Centre Hospitalier F.H. Manhes Fleury-Merogis, Hospital Broussais, Paris, France.
Circulation
|July 1, 1990
まとめ
ニートレンディピンは,低血圧を引き起こすことなく,血液透析患者の血圧を効果的に低下させました. この抗高血圧効果は,流体収縮と動脈の硬化と心臓機能の改善を有する患者でより顕著であった.
科学分野:
- ネフロロジーはネフロロジーを用います.
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- 高血圧は,長期的な血液透析を受けている患者の一般的な合併症です.
- この集団における血圧と心血管疾患の危険因子の管理は極めて重要です.
研究 の 目的:
- 血圧高血圧透析患者における血圧と動脈の硬さに対するニトレンジピン単独治療の有効性と効果を評価する.
主な方法:
- 40人の高血圧血液透析患者を含む24週間の,ダブルブラインド,プラセボランダム化研究.
- 測定には,血圧,心拍,脈波速度 (大動脈および外周) が含まれていた.
主要な成果:
- ニトレンディピンは,透析後の低血圧を引き起こすことなく,血圧を血析前の血圧を著しく低下させた.
- 薬剤の効果は,インターダイアリスティックでの体重増加 (液体保持) が大きい患者でより顕著でした.
- ニトレンディピンは,大動脈と股関節の脈波速度を低下させ,左心室の射出分数を増加させ,動脈の硬さの変化と相関していた.
結論:
- ニートレンディピンは,ヘモダイアリス患者,特に流体収縮患者において効果的な抗高血圧剤です.
- 治療により,動脈の硬化と左心室の機能が改善され,これは血圧の低下だけでは関係ありません.
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