古代の差異を推論するには,強力な系統遺伝信号を持つ遺伝子が必要です
Leonidas Salichos1, Antonis Rokas
1Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA.
Nature
|May 10, 2013
まとめ
系統遺伝学分析は遺伝子ツリーの不一致を明らかにし,標準的な方法に挑戦しています. 進化の歴史を正確に再構築するために,高原遺伝的支持を持つ遺伝子を選択することは極めて重要です.
科学分野:
- 進化生物学の進化生物学について
- ゲノミクスゲノミクスとは
- バイオインフォマティックス
背景:
- 系統遺伝学の研究では,しばしば遺伝子ツリー間のトポロジカル衝突 (不一致) に直面する.
- コンカンテネーションや流儀的分類種の除去などの現在の方法は,不一致を軽減しようとしています.
- 系統遺伝的推論の信頼性は,遺伝子ツリーの不一致に対処することに依存しています.
研究 の 目的:
- 系統遺伝学分析における不一致の影響を調査する.
- 不一致を解決する共通の慣行の有効性を評価する.
- 堅固な系統遺伝的再建のための最適な戦略を特定する.
主な方法:
- 23の酵母ゲノムから1,070のオルトロジの系統遺伝学分析.
- 推論された個々の遺伝子ツリーと連結した系統遺伝.
- 不一致の重度と遺伝子/内部節選択基準の影響を評価した.
主要な成果:
- 1,070の不一致の遺伝子ツリーが特定され,連鎖的系統形成と矛盾しています.
- 不一致は,線形遺伝のより深いところにあるより短い内部節とともに増加した.
- 高平均の内部節は,系統遺伝的推論の強度が著しく改善されたことを支持しています.
結論:
- コンケネネーションのような標準的な慣行は,正確な古代ディバージェンスの再構築には不十分かもしれません.
- 強い系統遺伝信号を持つ遺伝子を選択することは不可欠です.
- 重要な不一致の欠如を示すことは,系統遺伝的正確性を高めます.
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